Drug interactions
Fluconazole + Osilodrostat
Severity: Moderate
Fluconazole and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and fluconazole also has QT-prolonging potential. Combined use increases the risk of arrhythmia, especially if hypokalemia or hypomagnesemia is present, which can occur with adrenal steroid inhibition.
What this interaction means in plain words
Fluconazole and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc interval prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy, correcting potassium and magnesium abnormalities. Consider an alternative antifungal if QTc prolongs significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Fluconazole with Osilodrostat?
MediHelp rates the interaction as moderate. Fluconazole and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and fluconazole also has QT-prolonging potential. Combined use increases the risk of arrhythmia, especially if hypokalemia or hypomagnesemia is present, which can occur with adrenal steroid inhibition.
How serious is the interaction between Fluconazole and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, correcting potassium and magnesium abnormalities. Consider an alternative antifungal if QTc prolongs significantly.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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