Drug interactions
Fluconazole + Osimertinib
Severity: Moderate
Fluconazole and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib causes dose-dependent QTc prolongation, and fluconazole has additional QT-prolonging potential. Concurrent use may increase the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Fluconazole and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of the QTc interval.
What to do
Perform periodic ECG and electrolyte monitoring and correct abnormalities. Withhold or reconsider treatment if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Fluconazole with Osimertinib?
MediHelp rates the interaction as moderate. Fluconazole and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib causes dose-dependent QTc prolongation, and fluconazole has additional QT-prolonging potential. Concurrent use may increase the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Fluconazole and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring and correct abnormalities. Withhold or reconsider treatment if QTc becomes markedly prolonged.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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