Drug interactions
Fluconazole + Paliperidone
Severity: Moderate
Fluconazole and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fluconazole and paliperidone can prolong the QT interval. Used together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance, bradycardia or renal impairment.
What this interaction means in plain words
Fluconazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Paliperidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during co-therapy. Avoid adding other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Fluconazole with Paliperidone?
MediHelp rates the interaction as moderate. Fluconazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both fluconazole and paliperidone can prolong the QT interval. Used together they may increase the risk of torsades de pointes, particularly with electrolyte disturbance, bradycardia or renal impairment.
How serious is the interaction between Fluconazole and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc during co-therapy. Avoid adding other QT-prolonging agents.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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