Drug interactions
Fluconazole + Piroxicam
Severity: Moderate
Fluconazole and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a CYP2C9 inhibitor and can raise piroxicam concentrations, since piroxicam relies on CYP2C9 for clearance. Higher exposure may increase gastrointestinal, renal and bleeding risks, particularly as piroxicam has a long half-life.
What this interaction means in plain words
Fluconazole and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Piroxicam belongs to Musculoskeletal.
Why it happens
Fluconazole inhibits CYP2C9-mediated metabolism of piroxicam.
What to do
Use the lowest effective piroxicam dose, consider dose reduction, and monitor for gastrointestinal bleeding and renal effects. Consider an NSAID less dependent on CYP2C9 if prolonged fluconazole is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Piroxicam?
MediHelp rates the interaction as moderate. Fluconazole and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a CYP2C9 inhibitor and can raise piroxicam concentrations, since piroxicam relies on CYP2C9 for clearance. Higher exposure may increase gastrointestinal, renal and bleeding risks, particularly as piroxicam has a long half-life.
How serious is the interaction between Fluconazole and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective piroxicam dose, consider dose reduction, and monitor for gastrointestinal bleeding and renal effects. Consider an NSAID less dependent on CYP2C9 if prolonged fluconazole is needed.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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