Drug interactions
Fluconazole + Rimegepant
Severity: Moderate
Fluconazole and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and raises rimegepant exposure. This may increase the risk of adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Fluconazole and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by fluconazole reduces rimegepant metabolism.
What to do
Avoid taking a second rimegepant dose within 48 hours while on fluconazole. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Fluconazole with Rimegepant?
MediHelp rates the interaction as moderate. Fluconazole and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and raises rimegepant exposure. This may increase the risk of adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Fluconazole and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours while on fluconazole. Monitor for adverse effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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