Drug interactions
Fluconazole + Tazemetostat
Severity: Major
Fluconazole and Tazemetostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase tazemetostat concentrations, raising the risk of dose-related adverse effects. Tazemetostat is a CYP3A4 substrate.
What this interaction means in plain words
Fluconazole and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Tazemetostat belongs to Miscellaneous.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of tazemetostat.
What to do
Avoid if possible; if needed, reduce the tazemetostat dose per labeling and monitor for toxicity. Return to the previous dose after the inhibitor has been stopped for about three half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Fluconazole with Tazemetostat?
MediHelp rates the interaction as major. Fluconazole and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can increase tazemetostat concentrations, raising the risk of dose-related adverse effects. Tazemetostat is a CYP3A4 substrate.
How serious is the interaction between Fluconazole and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, reduce the tazemetostat dose per labeling and monitor for toxicity. Return to the previous dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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