Drug interactions
Fluconazole + Tipranavir
Severity: Moderate
Fluconazole and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise tipranavir concentrations, increasing the risk of tipranavir toxicity such as hepatotoxicity and intracranial hemorrhage. Tipranavir with ritonavir may in turn increase fluconazole levels modestly.
What this interaction means in plain words
Fluconazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Tipranavir belongs to Anti Virals.
Why it happens
Fluconazole inhibits CYP3A4 and CYP2C9, reducing tipranavir clearance.
What to do
Monitor liver enzymes and clinical status. Avoid fluconazole doses above 200 mg/day in patients on tipranavir, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fluconazole with Tipranavir?
MediHelp rates the interaction as moderate. Fluconazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise tipranavir concentrations, increasing the risk of tipranavir toxicity such as hepatotoxicity and intracranial hemorrhage. Tipranavir with ritonavir may in turn increase fluconazole levels modestly.
How serious is the interaction between Fluconazole and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and clinical status. Avoid fluconazole doses above 200 mg/day in patients on tipranavir, per labeling.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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