Drug interactions
Fluconazole + Vemurafenib
Severity: Major
Fluconazole and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use increases the risk of torsades de pointes. Vemurafenib causes concentration-dependent QT prolongation.
What this interaction means in plain words
Fluconazole and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation; fluconazole may also raise vemurafenib exposure via CYP3A4 inhibition.
What to do
Avoid if possible; otherwise monitor ECG and electrolytes before and during treatment. Consider interrupting or reducing vemurafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Fluconazole with Vemurafenib?
MediHelp rates the interaction as major. Fluconazole and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use increases the risk of torsades de pointes. Vemurafenib causes concentration-dependent QT prolongation.
How serious is the interaction between Fluconazole and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and electrolytes before and during treatment. Consider interrupting or reducing vemurafenib if QTc becomes markedly prolonged.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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