Drug interactions
Flucytosine + Itraconazole
Severity: Minor
Flucytosine and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flucytosine and azoles are sometimes used together for cryptococcal or other invasive fungal infections, with possible additive antifungal activity. No clear adverse pharmacokinetic interaction is established, though flucytosine can cause marrow and hepatic toxicity.
What this interaction means in plain words
Flucytosine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flucytosine belongs to Anti Fungals; Itraconazole belongs to Anti Fungals.
Why it happens
Complementary antifungal mechanisms with possible pharmacodynamic synergy; no established pharmacokinetic interaction.
What to do
Monitor blood counts and liver tests as needed for flucytosine therapy. Adjust flucytosine for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Flucytosine
- Amphotericin b + Flucytosine Major
- Deferiprone + Flucytosine Major
- Flucytosine + Ifosfamide Major
- Flucytosine + Lomustine Major
- Fluconazole + Flucytosine Moderate
- Flucytosine + Ganciclovir Moderate
Frequently asked questions
Can I take Flucytosine with Itraconazole?
MediHelp rates the interaction as minor. Flucytosine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flucytosine and azoles are sometimes used together for cryptococcal or other invasive fungal infections, with possible additive antifungal activity. No clear adverse pharmacokinetic interaction is established, though flucytosine can cause marrow and hepatic toxicity.
How serious is the interaction between Flucytosine and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver tests as needed for flucytosine therapy. Adjust flucytosine for renal function.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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