Drug interactions
Fluoxetine + Nitisinone
Severity: Minor
Fluoxetine and Nitisinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, which contributes to fluoxetine metabolism, so fluoxetine levels may rise. Increased exposure could cause more serotonergic adverse effects, though the effect is expected to be modest.
What this interaction means in plain words
Fluoxetine and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Nitisinone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2C9-mediated metabolism of fluoxetine by nitisinone.
What to do
Watch for fluoxetine adverse effects such as nausea, agitation or insomnia and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Fluoxetine with Nitisinone?
MediHelp rates the interaction as minor. Fluoxetine and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9, which contributes to fluoxetine metabolism, so fluoxetine levels may rise. Increased exposure could cause more serotonergic adverse effects, though the effect is expected to be modest.
How serious is the interaction between Fluoxetine and Nitisinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for fluoxetine adverse effects such as nausea, agitation or insomnia and reduce the dose if they occur.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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