Drug interactions
Fluoxetine + Prochlorperazine
Severity: Moderate
Fluoxetine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2D6 and may increase prochlorperazine exposure, increasing sedation, extrapyramidal effects and QT effects. Both drugs can prolong the QT interval, raising arrhythmia risk, and fluoxetine may also contribute to extrapyramidal symptoms.
What this interaction means in plain words
Fluoxetine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by fluoxetine plus additive QT prolongation.
What to do
Monitor for extrapyramidal symptoms, sedation and QT-related symptoms, with ECG in high-risk patients. Reduce the prochlorperazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Prochlorperazine?
MediHelp rates the interaction as moderate. Fluoxetine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine inhibits CYP2D6 and may increase prochlorperazine exposure, increasing sedation, extrapyramidal effects and QT effects. Both drugs can prolong the QT interval, raising arrhythmia risk, and fluoxetine may also contribute to extrapyramidal symptoms.
How serious is the interaction between Fluoxetine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QT-related symptoms, with ECG in high-risk patients. Reduce the prochlorperazine dose if adverse effects appear.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
