Drug interactions
Fluphenazine + Hydroxychloroquine
Severity: Major
Fluphenazine and Hydroxychloroquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
What this interaction means in plain words
Fluphenazine and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive blockade of cardiac repolarizing potassium currents (hERG) leading to QT prolongation.
What to do
Avoid the combination where an alternative exists; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG after starting.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Hydroxychloroquine?
MediHelp rates the interaction as major. Fluphenazine and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
How serious is the interaction between Fluphenazine and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG after starting.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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