Drug interactions
Fluphenazine + Indacaterol
Severity: Moderate
Fluphenazine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine, a phenothiazine, can prolong the QT interval, and indacaterol may add to this through cardiac stimulation and hypokalemia. The combination may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Fluphenazine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG in at-risk patients and keep potassium and magnesium normal. Monitor QTc and review the regimen if it lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Indacaterol?
MediHelp rates the interaction as moderate. Fluphenazine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine, a phenothiazine, can prolong the QT interval, and indacaterol may add to this through cardiac stimulation and hypokalemia. The combination may increase the risk of ventricular arrhythmias.
How serious is the interaction between Fluphenazine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in at-risk patients and keep potassium and magnesium normal. Monitor QTc and review the regimen if it lengthens.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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