Drug interactions
Fluphenazine + Midodrine
Severity: Moderate
Fluphenazine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-blocking activity that may oppose the vasopressor effect of midodrine and reduce its benefit in orthostatic hypotension. The interaction is not well documented.
What this interaction means in plain words
Fluphenazine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism between phenothiazine alpha-1 adrenergic blockade and midodrine alpha-1 agonism.
What to do
Monitor supine and standing blood pressure and adjust midodrine dose if response is reduced. Consider an antipsychotic with less alpha-blockade if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Fluphenazine with Midodrine?
MediHelp rates the interaction as moderate. Fluphenazine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has alpha-blocking activity that may oppose the vasopressor effect of midodrine and reduce its benefit in orthostatic hypotension. The interaction is not well documented.
How serious is the interaction between Fluphenazine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and adjust midodrine dose if response is reduced. Consider an antipsychotic with less alpha-blockade if hypotension persists.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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