Drug interactions
Fluphenazine + Modafinil
Severity: Moderate
Fluphenazine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is an antipsychotic that causes sedation, whereas modafinil promotes wakefulness, so the effects oppose each other. Modafinil may aggravate psychiatric symptoms such as anxiety or psychosis in susceptible patients.
What this interaction means in plain words
Fluphenazine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; dopamine antagonism versus dopamine reuptake inhibition.
What to do
Monitor psychiatric symptoms and sedation, and reassess the need for modafinil if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Modafinil?
MediHelp rates the interaction as moderate. Fluphenazine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is an antipsychotic that causes sedation, whereas modafinil promotes wakefulness, so the effects oppose each other. Modafinil may aggravate psychiatric symptoms such as anxiety or psychosis in susceptible patients.
How serious is the interaction between Fluphenazine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and sedation, and reassess the need for modafinil if symptoms worsen.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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