Drug interactions
Fluphenazine + Oxycodone
Severity: Moderate
Fluphenazine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine and oxycodone both depress the CNS, so combined use increases sedation, hypotension and possibly respiratory depression. Opioid-related constipation and anticholinergic effects may also be additive.
What this interaction means in plain words
Fluphenazine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from dopamine antagonism and opioid receptor agonism.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiratory rate, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Oxycodone?
MediHelp rates the interaction as moderate. Fluphenazine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine and oxycodone both depress the CNS, so combined use increases sedation, hypotension and possibly respiratory depression. Opioid-related constipation and anticholinergic effects may also be additive.
How serious is the interaction between Fluphenazine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiratory rate, particularly in older patients.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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