Drug interactions
Fluphenazine + Ozanimod
Severity: Moderate
Fluphenazine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and fluphenazine can prolong the QT interval. Together they may increase the risk of arrhythmia, especially bradycardia-related torsades.
What this interaction means in plain words
Fluphenazine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of ozanimod-induced bradycardia and fluphenazine QT prolongation.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice if QT-prolonging drugs cannot be avoided. Monitor heart rate and QTc afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Fluphenazine with Ozanimod?
MediHelp rates the interaction as moderate. Fluphenazine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and fluphenazine can prolong the QT interval. Together they may increase the risk of arrhythmia, especially bradycardia-related torsades.
How serious is the interaction between Fluphenazine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice if QT-prolonging drugs cannot be avoided. Monitor heart rate and QTc afterwards.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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