Drug interactions
Fluphenazine + Ranolazine
Severity: Major
Fluphenazine and Ranolazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine and fluphenazine can both prolong the QT interval, so combined use may increase the risk of torsades de pointes. Ranolazine's moderate CYP2D6 inhibition may also raise fluphenazine levels, adding to the risk.
What this interaction means in plain words
Fluphenazine and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with possible increased fluphenazine exposure from CYP2D6 inhibition by ranolazine.
What to do
Avoid the combination if possible; if used, check a baseline and follow-up ECG, correct electrolytes, and use the lowest effective fluphenazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Ranolazine?
MediHelp rates the interaction as major. Fluphenazine and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ranolazine and fluphenazine can both prolong the QT interval, so combined use may increase the risk of torsades de pointes. Ranolazine's moderate CYP2D6 inhibition may also raise fluphenazine levels, adding to the risk.
How serious is the interaction between Fluphenazine and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, check a baseline and follow-up ECG, correct electrolytes, and use the lowest effective fluphenazine dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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