Drug interactions
Fluphenazine + Risperidone
Severity: Major
Fluphenazine and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use increases the risk of extrapyramidal symptoms, sedation, neuroleptic malignant syndrome and QT prolongation. Fluphenazine may also raise risperidone levels via CYP2D6 competition.
What this interaction means in plain words
Fluphenazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluphenazine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive D2 blockade and QT prolongation, plus possible CYP2D6 competition.
What to do
Avoid combining antipsychotics where possible. If used, keep doses low, monitor ECG and electrolytes, and watch for movement disorders.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Fluphenazine with Risperidone?
MediHelp rates the interaction as major. Fluphenazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined use increases the risk of extrapyramidal symptoms, sedation, neuroleptic malignant syndrome and QT prolongation. Fluphenazine may also raise risperidone levels via CYP2D6 competition.
How serious is the interaction between Fluphenazine and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining antipsychotics where possible. If used, keep doses low, monitor ECG and electrolytes, and watch for movement disorders.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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