Drug interactions
Fluphenazine + Sevoflurane
Severity: Moderate
Fluphenazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine may potentiate the sedative and hypotensive effects of sevoflurane, and both can prolong the QT interval. Perioperative arrhythmia risk may be increased.
What this interaction means in plain words
Fluphenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression, vasodilation and QT prolongation.
What to do
Inform the anesthesia team of antipsychotic use and monitor ECG and blood pressure intraoperatively. Correct electrolytes beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Fluphenazine with Sevoflurane?
MediHelp rates the interaction as moderate. Fluphenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine may potentiate the sedative and hypotensive effects of sevoflurane, and both can prolong the QT interval. Perioperative arrhythmia risk may be increased.
How serious is the interaction between Fluphenazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of antipsychotic use and monitor ECG and blood pressure intraoperatively. Correct electrolytes beforehand.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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