Drug interactions
Fluphenazine + Stiripentol
Severity: Moderate
Fluphenazine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so taking them together can produce greater drowsiness, somnolence and impaired psychomotor performance. Stiripentol also inhibits several CYP enzymes, which could raise levels of CYP2D6-metabolised phenothiazines such as fluphenazine.
What this interaction means in plain words
Fluphenazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP inhibition by stiripentol reducing fluphenazine clearance.
What to do
Monitor for excessive sedation and extrapyramidal symptoms when starting or changing doses. Reduce the fluphenazine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Fluphenazine with Stiripentol?
MediHelp rates the interaction as moderate. Fluphenazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so taking them together can produce greater drowsiness, somnolence and impaired psychomotor performance. Stiripentol also inhibits several CYP enzymes, which could raise levels of CYP2D6-metabolised phenothiazines such as fluphenazine.
How serious is the interaction between Fluphenazine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and extrapyramidal symptoms when starting or changing doses. Reduce the fluphenazine dose if adverse effects emerge.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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