Drug interactions
Fluphenazine + Tiotropium-olodaterol
Severity: Moderate
Fluphenazine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can prolong the QT interval and has anticholinergic activity. Olodaterol may add to QT effects, while tiotropium adds to antimuscarinic effects.
What this interaction means in plain words
Fluphenazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Monitor ECG and electrolytes in at-risk patients, and watch for anticholinergic effects such as urinary retention and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fluphenazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can prolong the QT interval and has anticholinergic activity. Olodaterol may add to QT effects, while tiotropium adds to antimuscarinic effects.
How serious is the interaction between Fluphenazine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in at-risk patients, and watch for anticholinergic effects such as urinary retention and constipation.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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