Drug interactions
Fluphenazine + Tramadol
Severity: Moderate
Fluphenazine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines add to opioid sedation and hypotension, and both drugs lower the seizure threshold. Fluphenazine is a CYP2D6 substrate and inhibitor, which may reduce activation of tramadol.
What this interaction means in plain words
Fluphenazine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and seizure threshold lowering, with possible CYP2D6 inhibition.
What to do
Monitor sedation, blood pressure, seizures and analgesic effect, and use lower starting doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Tramadol?
MediHelp rates the interaction as moderate. Fluphenazine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines add to opioid sedation and hypotension, and both drugs lower the seizure threshold. Fluphenazine is a CYP2D6 substrate and inhibitor, which may reduce activation of tramadol.
How serious is the interaction between Fluphenazine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure, seizures and analgesic effect, and use lower starting doses.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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