Drug interactions
Flutamide + Posaconazole
Severity: Moderate
Flutamide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole strongly inhibits CYP3A4 and may reduce the clearance of flutamide, which is metabolized partly by CYP1A2 and CYP3A4. Higher exposure to flutamide or its active metabolite could increase the risk of its dose-related hepatotoxicity.
What this interaction means in plain words
Flutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of flutamide.
What to do
Monitor liver enzymes and bilirubin regularly and counsel the patient to report jaundice, dark urine or abdominal pain. Stop flutamide if hepatic injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Flutamide
Frequently asked questions
Can I take Flutamide with Posaconazole?
MediHelp rates the interaction as moderate. Flutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole strongly inhibits CYP3A4 and may reduce the clearance of flutamide, which is metabolized partly by CYP1A2 and CYP3A4. Higher exposure to flutamide or its active metabolite could increase the risk of its dose-related hepatotoxicity.
How serious is the interaction between Flutamide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin regularly and counsel the patient to report jaundice, dark urine or abdominal pain. Stop flutamide if hepatic injury develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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