Drug interactions
Flutamide + Teriflunomide
Severity: Moderate
Flutamide and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flutamide is activated and cleared by CYP1A2, and teriflunomide is a weak CYP1A2 inducer. Exposure to flutamide and its active metabolite might shift slightly, with limited clinical effect. Both drugs can cause liver injury, which is the more relevant concern.
What this interaction means in plain words
Flutamide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP1A2 induction by teriflunomide may alter flutamide metabolism, and the two drugs have additive hepatotoxic potential.
What to do
Monitor liver enzymes regularly during the combination and stop either drug if significant liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Flutamide
Frequently asked questions
Can I take Flutamide with Teriflunomide?
MediHelp rates the interaction as moderate. Flutamide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flutamide is activated and cleared by CYP1A2, and teriflunomide is a weak CYP1A2 inducer. Exposure to flutamide and its active metabolite might shift slightly, with limited clinical effect. Both drugs can cause liver injury, which is the more relevant concern.
How serious is the interaction between Flutamide and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly during the combination and stop either drug if significant liver injury develops.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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