Drug interactions
Flutamide + Tucatinib
Severity: Moderate
Flutamide and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise flutamide exposure. Because flutamide can cause serious liver injury, increased exposure and tucatinib's own hepatic effects are a concern.
What this interaction means in plain words
Flutamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by tucatinib reduces flutamide metabolism.
What to do
Monitor liver enzymes regularly and consider an alternative antiandrogen. Stop therapy if liver injury is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Flutamide with Tucatinib?
MediHelp rates the interaction as moderate. Flutamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise flutamide exposure. Because flutamide can cause serious liver injury, increased exposure and tucatinib's own hepatic effects are a concern.
How serious is the interaction between Flutamide and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly and consider an alternative antiandrogen. Stop therapy if liver injury is suspected.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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