Drug interactions
Fluticasone-salmeterol + Solriamfetol
Severity: Moderate
Fluticasone-salmeterol and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises blood pressure and heart rate, and salmeterol has sympathomimetic cardiovascular effects. Combined use may increase tachycardia and hypertension.
What this interaction means in plain words
Fluticasone-salmeterol and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive adrenergic and cardiovascular stimulation from dopamine/norepinephrine reuptake inhibition and beta-2 agonism.
What to do
Monitor blood pressure and heart rate during combined use. Adjust therapy if sustained increases occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Solriamfetol?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol raises blood pressure and heart rate, and salmeterol has sympathomimetic cardiovascular effects. Combined use may increase tachycardia and hypertension.
How serious is the interaction between Fluticasone-salmeterol and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during combined use. Adjust therapy if sustained increases occur.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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