Drug interactions
Fluticasone-vilanterol + Pentamidine
Severity: Major
Fluticasone-vilanterol and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, particularly when given systemically, can prolong the QTc interval and cause torsades de pointes. Vilanterol may add to arrhythmic risk through its cardiac and potassium-lowering effects.
What this interaction means in plain words
Fluticasone-vilanterol and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible beta-agonist-related hypokalemia.
What to do
Monitor ECG and correct potassium and magnesium before and during pentamidine therapy. Consider alternatives to the beta-agonist if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Pentamidine?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine, particularly when given systemically, can prolong the QTc interval and cause torsades de pointes. Vilanterol may add to arrhythmic risk through its cardiac and potassium-lowering effects.
How serious is the interaction between Fluticasone-vilanterol and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during pentamidine therapy. Consider alternatives to the beta-agonist if QTc becomes prolonged.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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