Drug interactions
Fluticasone-vilanterol + Posaconazole
Severity: Major
Fluticasone-vilanterol and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor that can raise exposure to both vilanterol and fluticasone furoate, and it also prolongs the QT interval. This can increase beta-agonist cardiac effects and systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-vilanterol and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 and P-gp inhibition raises vilanterol and fluticasone furoate exposure, with additive QT effects.
What to do
Avoid the combination where possible; if used, monitor ECG, potassium and signs of corticosteroid excess such as adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-vilanterol and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Posaconazole?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor that can raise exposure to both vilanterol and fluticasone furoate, and it also prolongs the QT interval. This can increase beta-agonist cardiac effects and systemic corticosteroid effects.
How serious is the interaction between Fluticasone-vilanterol and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor ECG, potassium and signs of corticosteroid excess such as adrenal suppression.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
