Drug interactions
Fluticasone-vilanterol + Tucatinib
Severity: Moderate
Fluticasone-vilanterol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase exposure to vilanterol and fluticasone furoate. This could increase beta-agonist cardiovascular effects and systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-vilanterol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilanterol and fluticasone furoate.
What to do
Monitor heart rate, blood pressure, potassium and signs of corticosteroid excess. Consider a bronchodilator with less CYP3A4 dependence if tolerance is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Tucatinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase exposure to vilanterol and fluticasone furoate. This could increase beta-agonist cardiovascular effects and systemic corticosteroid effects.
How serious is the interaction between Fluticasone-vilanterol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, potassium and signs of corticosteroid excess. Consider a bronchodilator with less CYP3A4 dependence if tolerance is poor.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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