Drug interactions
Fluvoxamine + Levamlodipine
Severity: Minor
Fluvoxamine and Levamlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine is the active enantiomer of amlodipine and is cleared by CYP3A4. Fluvoxamine may modestly increase its concentration, leading to more hypotension, dizziness or peripheral edema.
What this interaction means in plain words
Fluvoxamine and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Levamlodipine belongs to Cardiovascular.
Why it happens
Weak to moderate CYP3A4 inhibition by fluvoxamine reduces levamlodipine metabolism.
What to do
Monitor blood pressure and for peripheral edema after starting fluvoxamine. Reduce the levamlodipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Fluvoxamine with Levamlodipine?
MediHelp rates the interaction as minor. Fluvoxamine and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levamlodipine is the active enantiomer of amlodipine and is cleared by CYP3A4. Fluvoxamine may modestly increase its concentration, leading to more hypotension, dizziness or peripheral edema.
How serious is the interaction between Fluvoxamine and Levamlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral edema after starting fluvoxamine. Reduce the levamlodipine dose if hypotension or edema occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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