Drug interactions
Fluvoxamine + Lopinavir
Severity: Moderate
Fluvoxamine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may mildly increase lopinavir levels via CYP3A4 inhibition. Lopinavir/ritonavir may in turn raise fluvoxamine exposure and prolong the QT interval, so the interaction can run in both directions.
What this interaction means in plain words
Fluvoxamine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by fluvoxamine; additive QT effects are also possible.
What to do
Monitor for adverse effects of both drugs, and obtain an ECG if other QT-prolonging risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Lopinavir?
MediHelp rates the interaction as moderate. Fluvoxamine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine may mildly increase lopinavir levels via CYP3A4 inhibition. Lopinavir/ritonavir may in turn raise fluvoxamine exposure and prolong the QT interval, so the interaction can run in both directions.
How serious is the interaction between Fluvoxamine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of both drugs, and obtain an ECG if other QT-prolonging risk factors exist.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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