Drug interactions
Fluvoxamine + Omaveloxolone
Severity: Moderate
Fluvoxamine and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized mainly by CYP3A4, and moderate inhibitors increase exposure, raising the risk of liver enzyme elevations and other adverse effects. Fluvoxamine inhibits CYP3A4 to a modest extent.
What this interaction means in plain words
Fluvoxamine and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing omaveloxolone clearance.
What to do
Avoid if possible; otherwise reduce the omaveloxolone dose as labeled and monitor liver enzymes, bilirubin, lipids and BNP.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Fluvoxamine with Omaveloxolone?
MediHelp rates the interaction as moderate. Fluvoxamine and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is metabolized mainly by CYP3A4, and moderate inhibitors increase exposure, raising the risk of liver enzyme elevations and other adverse effects. Fluvoxamine inhibits CYP3A4 to a modest extent.
How serious is the interaction between Fluvoxamine and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the omaveloxolone dose as labeled and monitor liver enzymes, bilirubin, lipids and BNP.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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