Drug interactions
Fluvoxamine + Pregabalin
Severity: Moderate
Fluvoxamine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes sedation and dizziness, and fluvoxamine may add to drowsiness and psychomotor impairment. Respiratory depression is mainly a concern in vulnerable patients or when other CNS depressants such as opioids are also used.
What this interaction means in plain words
Fluvoxamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, which are pharmacodynamic.
What to do
Use the lowest effective pregabalin dose with gradual titration, and monitor for sedation, dizziness and respiratory depression. Take particular care in patients with respiratory disease or on other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Fluvoxamine with Pregabalin?
MediHelp rates the interaction as moderate. Fluvoxamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin causes sedation and dizziness, and fluvoxamine may add to drowsiness and psychomotor impairment. Respiratory depression is mainly a concern in vulnerable patients or when other CNS depressants such as opioids are also used.
How serious is the interaction between Fluvoxamine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pregabalin dose with gradual titration, and monitor for sedation, dizziness and respiratory depression. Take particular care in patients with respiratory disease or on other sedatives.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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