Drug interactions
Fluvoxamine + Repotrectinib
Severity: Moderate
Fluvoxamine and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is metabolized by CYP3A4, and inhibitors raise its exposure, which may worsen neurologic toxicity such as dizziness and ataxia. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
What this interaction means in plain words
Fluvoxamine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing repotrectinib clearance.
What to do
Monitor for CNS adverse effects and consider an alternative antidepressant with minimal CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Fluvoxamine with Repotrectinib?
MediHelp rates the interaction as moderate. Fluvoxamine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is metabolized by CYP3A4, and inhibitors raise its exposure, which may worsen neurologic toxicity such as dizziness and ataxia. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
How serious is the interaction between Fluvoxamine and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and consider an alternative antidepressant with minimal CYP3A4 inhibition.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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