Drug interactions
Fluvoxamine + Risperidone
Severity: Moderate
Fluvoxamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may modestly raise risperidone levels via CYP2D6 and CYP3A4 inhibition, increasing extrapyramidal and sedative effects. Both drugs have some QT-prolonging potential.
What this interaction means in plain words
Fluvoxamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Inhibition of risperidone metabolism by fluvoxamine plus additive QT effects.
What to do
Start with a lower risperidone dose and monitor for extrapyramidal symptoms and sedation. Check an ECG in patients with additional QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Fluvoxamine with Risperidone?
MediHelp rates the interaction as moderate. Fluvoxamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine may modestly raise risperidone levels via CYP2D6 and CYP3A4 inhibition, increasing extrapyramidal and sedative effects. Both drugs have some QT-prolonging potential.
How serious is the interaction between Fluvoxamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower risperidone dose and monitor for extrapyramidal symptoms and sedation. Check an ECG in patients with additional QT risk.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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