Drug interactions
Fluvoxamine + Rizatriptan
Severity: Moderate
Fluvoxamine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents enhance serotonergic transmission, so combined use may rarely cause serotonin syndrome. Rizatriptan is cleared mainly by MAO-A, which fluvoxamine does not meaningfully inhibit, so the interaction is mainly pharmacodynamic.
What this interaction means in plain words
Fluvoxamine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from 5-HT1B/1D agonism plus serotonin reuptake inhibition.
What to do
Counsel on symptoms of serotonin toxicity and monitor, especially at initiation or dose increases. Stop rizatriptan if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Rizatriptan?
MediHelp rates the interaction as moderate. Fluvoxamine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents enhance serotonergic transmission, so combined use may rarely cause serotonin syndrome. Rizatriptan is cleared mainly by MAO-A, which fluvoxamine does not meaningfully inhibit, so the interaction is mainly pharmacodynamic.
How serious is the interaction between Fluvoxamine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms of serotonin toxicity and monitor, especially at initiation or dose increases. Stop rizatriptan if symptoms develop.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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