Drug interactions
Fluvoxamine + Sevoflurane
Severity: Moderate
Fluvoxamine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT interval prolongation, so combined exposure during anesthesia may add to the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Fluvoxamine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects.
What to do
Obtain a baseline ECG for patients with QT risk factors and correct potassium and magnesium before surgery. Monitor the ECG during and after anesthesia and avoid adding other QT-prolonging drugs such as certain antiemetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Fluvoxamine with Sevoflurane?
MediHelp rates the interaction as moderate. Fluvoxamine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT interval prolongation, so combined exposure during anesthesia may add to the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Fluvoxamine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG for patients with QT risk factors and correct potassium and magnesium before surgery. Monitor the ECG during and after anesthesia and avoid adding other QT-prolonging drugs such as certain antiemetics.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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