Drug interactions
Fluvoxamine + Sotalol
Severity: Moderate
Fluvoxamine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, and combined use may increase the risk of torsades de pointes. Fluvoxamine may also add to bradycardia.
What this interaction means in plain words
Fluvoxamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation; fluvoxamine has relatively weak intrinsic effects, so the interaction is largely pharmacodynamic.
What to do
Check a baseline ECG and electrolytes and repeat the ECG after initiation or dose change. Prefer an alternative SSRI if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Sotalol?
MediHelp rates the interaction as moderate. Fluvoxamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, and combined use may increase the risk of torsades de pointes. Fluvoxamine may also add to bradycardia.
How serious is the interaction between Fluvoxamine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG after initiation or dose change. Prefer an alternative SSRI if QTc becomes prolonged.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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