Drug interactions
Fluvoxamine + Stiripentol
Severity: Moderate
Fluvoxamine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes, including CYP1A2 and CYP2C19, which participate in fluvoxamine clearance, while fluvoxamine strongly inhibits CYP1A2 and CYP2C19 itself. Levels of both drugs and of co-administered substrates such as clobazam may change. This can lead to increased sedation or other adverse effects.
What this interaction means in plain words
Fluvoxamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mutual inhibition of CYP1A2 and CYP2C19 metabolism.
What to do
Monitor for sedation, nausea and other adverse effects, and adjust doses of either drug as needed. Review other antiseizure drugs, as their levels may also change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Fluvoxamine with Stiripentol?
MediHelp rates the interaction as moderate. Fluvoxamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes, including CYP1A2 and CYP2C19, which participate in fluvoxamine clearance, while fluvoxamine strongly inhibits CYP1A2 and CYP2C19 itself. Levels of both drugs and of co-administered substrates such as clobazam may change. This can lead to increased sedation or other adverse effects.
How serious is the interaction between Fluvoxamine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, nausea and other adverse effects, and adjust doses of either drug as needed. Review other antiseizure drugs, as their levels may also change.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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