Drug interactions
Fluvoxamine + Temsirolimus
Severity: Moderate
Fluvoxamine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of adverse effects such as mucositis, hyperglycemia, hyperlipidemia and myelosuppression. The effect is predicted from the enzyme pathway involved.
What this interaction means in plain words
Fluvoxamine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, which metabolizes temsirolimus and sirolimus.
What to do
Monitor for temsirolimus toxicity and consider a dose reduction if adverse effects emerge. A non-CYP3A4-inhibiting antidepressant is preferable if one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Temsirolimus?
MediHelp rates the interaction as moderate. Fluvoxamine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of adverse effects such as mucositis, hyperglycemia, hyperlipidemia and myelosuppression. The effect is predicted from the enzyme pathway involved.
How serious is the interaction between Fluvoxamine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity and consider a dose reduction if adverse effects emerge. A non-CYP3A4-inhibiting antidepressant is preferable if one is suitable.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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