Drug interactions
Fluvoxamine + Valbenazine
Severity: Moderate
Fluvoxamine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and fluvoxamine has some QT liability. Fluvoxamine also inhibits CYP2C19 and CYP3A4, which may modestly increase valbenazine exposure.
What this interaction means in plain words
Fluvoxamine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with possible pharmacokinetic increase in valbenazine exposure.
What to do
Monitor ECG in patients with cardiac risk factors, and ensure electrolytes are normal. Watch for somnolence and consider valbenazine dose reduction if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Fluvoxamine with Valbenazine?
MediHelp rates the interaction as moderate. Fluvoxamine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and fluvoxamine has some QT liability. Fluvoxamine also inhibits CYP2C19 and CYP3A4, which may modestly increase valbenazine exposure.
How serious is the interaction between Fluvoxamine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors, and ensure electrolytes are normal. Watch for somnolence and consider valbenazine dose reduction if poorly tolerated.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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