Drug interactions
Fluvoxamine + Zonisamide
Severity: Minor
Fluvoxamine and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may increase zonisamide concentrations, which could intensify adverse effects such as drowsiness, dizziness, cognitive slowing and metabolic acidosis. The interaction is predicted from the metabolic pathway rather than well documented.
What this interaction means in plain words
Fluvoxamine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP3A4, a main pathway for zonisamide metabolism.
What to do
Monitor for sedation and other zonisamide adverse effects when fluvoxamine is added, and reduce the zonisamide dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Zonisamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Fluvoxamine with Zonisamide?
MediHelp rates the interaction as minor. Fluvoxamine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may increase zonisamide concentrations, which could intensify adverse effects such as drowsiness, dizziness, cognitive slowing and metabolic acidosis. The interaction is predicted from the metabolic pathway rather than well documented.
How serious is the interaction between Fluvoxamine and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other zonisamide adverse effects when fluvoxamine is added, and reduce the zonisamide dose if they occur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
