Drug interactions
Fondaparinux + Hemin
Severity: Moderate
Fondaparinux and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin and its degradation product hematin can have mild anticoagulant effects and may reduce platelet counts. Combined with fondaparinux this may increase bleeding risk.
What this interaction means in plain words
Fondaparinux and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Hemin belongs to Miscellaneous.
Why it happens
Additive anticoagulant and platelet effects of hematin with factor Xa inhibition.
What to do
Monitor for bleeding and check platelet count and coagulation status during hemin treatment in patients on fondaparinux.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Fondaparinux with Hemin?
MediHelp rates the interaction as moderate. Fondaparinux and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin and its degradation product hematin can have mild anticoagulant effects and may reduce platelet counts. Combined with fondaparinux this may increase bleeding risk.
How serious is the interaction between Fondaparinux and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check platelet count and coagulation status during hemin treatment in patients on fondaparinux.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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