Drug interactions
Fondaparinux + Vortioxetine
Severity: Moderate
Fondaparinux and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, a serotonergic antidepressant, can impair platelet function and may increase bleeding tendency when given with fondaparinux. Clinical data on this specific pair are limited, but the effect is expected from the class.
What this interaction means in plain words
Fondaparinux and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition reduces platelet serotonin stores and aggregation, adding to the anticoagulant effect of fondaparinux.
What to do
Monitor for bruising, mucosal bleeding and gastrointestinal bleeding, and check hemoglobin if symptoms arise. Review the need for ongoing combined therapy in patients with additional bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Fondaparinux with Vortioxetine?
MediHelp rates the interaction as moderate. Fondaparinux and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, a serotonergic antidepressant, can impair platelet function and may increase bleeding tendency when given with fondaparinux. Clinical data on this specific pair are limited, but the effect is expected from the class.
How serious is the interaction between Fondaparinux and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, mucosal bleeding and gastrointestinal bleeding, and check hemoglobin if symptoms arise. Review the need for ongoing combined therapy in patients with additional bleeding risk factors.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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