Drug interactions
Formoterol-mometasone + Leuprolide
Severity: Moderate
Formoterol-mometasone and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide-induced androgen deprivation can prolong the QT interval, and formoterol may add to QT effects and lower potassium. The combination might increase torsades de pointes risk in susceptible patients.
What this interaction means in plain words
Formoterol-mometasone and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation through androgen deprivation and beta-2 agonist effects.
What to do
Review ECG and electrolytes in patients with cardiac risk factors and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Formoterol-mometasone with Leuprolide?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide-induced androgen deprivation can prolong the QT interval, and formoterol may add to QT effects and lower potassium. The combination might increase torsades de pointes risk in susceptible patients.
How serious is the interaction between Formoterol-mometasone and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and electrolytes in patients with cardiac risk factors and correct hypokalemia.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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