Drug interactions
Fosaprepitant + Linagliptin
Severity: Minor
Fosaprepitant and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant (aprepitant) is a moderate CYP3A4 inhibitor and weak inducer, but linagliptin depends little on CYP3A4 for clearance. A clinically important change in linagliptin exposure from a single-dose or short course is not expected.
What this interaction means in plain words
Fosaprepitant and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Linagliptin belongs to Endocrine.
Why it happens
Aprepitant's mixed, transient CYP3A4 effects may slightly alter linagliptin metabolism, a minor elimination route.
What to do
No dose adjustment is needed; routine glucose monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Linagliptin?
MediHelp rates the interaction as minor. Fosaprepitant and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant (aprepitant) is a moderate CYP3A4 inhibitor and weak inducer, but linagliptin depends little on CYP3A4 for clearance. A clinically important change in linagliptin exposure from a single-dose or short course is not expected.
How serious is the interaction between Fosaprepitant and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine glucose monitoring is sufficient.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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