Drug interactions
Fosaprepitant + Loratadine
Severity: Minor
Fosaprepitant and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate and short-lived CYP3A4 inhibitor after single-dose use and may slightly raise loratadine exposure. Clinical impact is expected to be minimal.
What this interaction means in plain words
Fosaprepitant and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Loratadine belongs to Respiratory.
Why it happens
Weak to moderate CYP3A4 inhibition by aprepitant reduces loratadine clearance.
What to do
No adjustment is needed; monitor for drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Loratadine?
MediHelp rates the interaction as minor. Fosaprepitant and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, the active form of fosaprepitant, is a moderate and short-lived CYP3A4 inhibitor after single-dose use and may slightly raise loratadine exposure. Clinical impact is expected to be minimal.
How serious is the interaction between Fosaprepitant and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for drowsiness.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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