Drug interactions
Fosaprepitant + Methylprednisolone
Severity: Moderate
Fosaprepitant and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and raises methylprednisolone exposure. Labeling recommends reducing the dose of methylprednisolone when it is given with this antiemetic.
What this interaction means in plain words
Fosaprepitant and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Methylprednisolone belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4, decreasing methylprednisolone metabolism.
What to do
Reduce the oral or intravenous methylprednisolone dose by about half when given with fosaprepitant regimens, per labeling, and monitor for steroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Methylprednisolone?
MediHelp rates the interaction as moderate. Fosaprepitant and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and raises methylprednisolone exposure. Labeling recommends reducing the dose of methylprednisolone when it is given with this antiemetic.
How serious is the interaction between Fosaprepitant and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the oral or intravenous methylprednisolone dose by about half when given with fosaprepitant regimens, per labeling, and monitor for steroid adverse effects.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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