Drug interactions
Fosaprepitant + Palbociclib
Severity: Minor
Fosaprepitant and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, a prodrug of aprepitant, is a weak to moderate CYP3A4 inhibitor after single-dose use. It may modestly raise palbociclib concentrations, with a possible increase in myelosuppression.
What this interaction means in plain words
Fosaprepitant and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Palbociclib belongs to Oncology.
Why it happens
Aprepitant, formed from fosaprepitant, transiently inhibits CYP3A4, slightly reducing palbociclib clearance.
What to do
No routine dose change is needed with a single antiemetic dose. Monitor blood counts as part of standard palbociclib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palbociclib
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Palbociclib?
MediHelp rates the interaction as minor. Fosaprepitant and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, a prodrug of aprepitant, is a weak to moderate CYP3A4 inhibitor after single-dose use. It may modestly raise palbociclib concentrations, with a possible increase in myelosuppression.
How serious is the interaction between Fosaprepitant and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed with a single antiemetic dose. Monitor blood counts as part of standard palbociclib care.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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